Police received a call at 12:18 p.m. regarding a collision in Brampton.
Police say the collision occurred on Highway 50 and Cadetta Road.
Two vehicles were involved and one driver has been taken to a trauma center with serious injuries, according to police.
Northbound and southbound lanes are now closed.
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Police are advising drivers to look for alternate routes.
The driver taken to a trauma centre is in stable condition.